KETOCONAZOLE cream / Lotion/ shampoo (हिन्दी में) uses, how to apply
What Is Ketoconazole (Nizoral)?
Ketoconazole is the generic form of the brand name drug Nizoral.
It comes in cream and tablet form and is used to treat serious fungal infections when other medicines can't be taken.
Ketoconazole belongs to a class of drugs called imidazoles. It works by stopping the growth of fungus.
The medicine is manufactured by Janssen Pharmaceuticals, and was approved by the Food and Drug Administration (FDA) in 1981.
Ketoconazole for Hair Loss
Ketoconazole is sometimes used topically to treat hair loss. It's found in prescription and over-the-counter (OTC) shampoos.
While research isn't conclusive on the effectiveness of ketoconazole for treating hair loss, a study published in the Journal of Dermatology in 2005 found two-percent ketoconazole stimulated hair regrowth in mouse models.
Only a small amount of the medicine is absorbed by skin, so there are no serious side effects associated with the shampoo.
Ketoconazole for Dogs and Cats
Ketoconazole is sometimes used in dogs and cats to treat fungal and bacterial skin infections.
It's also used to treat Cushing's syndrome (a hormonal disorder caused by high levels of cortisol) in some pets.
Talk to your veterinarian about the benefits and risks of giving this medicine to your dog or cat.
The FDA requires a black-box warning on ketoconazole because the drug can cause serious liver damage that might result in the need for a liver transplant or death.
Call your doctor immediately if you experience any of the following symptoms of liver problems:
- Yellowing of the skin or eyes (jaundice)
- Upper stomach pain
- Loss of appetite
- Dark-colored urine
- Clay-colored stools
Consuming alcohol while taking ketoconazole may increase the risk of liver side effects. Avoid drinking alcohol while taking this medicine.
Tell your doctor if you have or have ever had any liver problems.
Ketoconazole may cause an irregular heart rhythm disorder known as QT prolongation. This condition can lead to seizures, loss of consciousness, fainting, or sudden death.
Stop taking ketoconazole and tell your doctor immediately if you experience:
- A fast, pounding, or irregular heartbeat
- Loss of consciousness
Don't take the following medications while using ketoconazole:
When ketoconazole is taken at high doses, it may cause an adrenal gland problem, a decrease in testosterone, and a decrease in sperm production.
Talk to your doctor about these possible risks, especially if you have a history of adrenal gland problems.
Also, tell your doctor if you take antacids, stomach acid reducers, or drugs to treat stomach ulcers or gastroesophageal reflux disease (GERD). These medicines may make it harder for your body to absorb ketoconazole.
Ketoconazole shouldn't be used to treat fungal infections in the brain or on the skin and nails.
Tell your doctor or dentist you're taking this medication before having any type of surgery, including a dental procedure.
Ketoconazole is sometimes prescribed for treating prostate cancer or Cushing's syndrome, but the drug hasn't been shown to be safe or effective for these uses. Talk to your doctor about using ketoconazole for these conditions.
You might need to take ketoconazole for six months or longer. Don't stop taking this medicine unless your doctor tells you to do so.
If you stop taking ketoconazole too soon, your infection may return after a short period of time.
Keep all doctor and laboratory appointments while taking this drug. Your doctor will likely test your blood often.
Pregnancy and Ketoconazole
Ketoconazole is in FDA Pregnancy Category C, which means it's not known whether it will harm an unborn baby.
Tell your doctor if you're pregnant or plan to become pregnant while taking this medicine.
This drug can pass into breast milk and may harm a breastfeeding baby. You shouldn't breastfeed while taking ketoconazole.
Ketoconazole Side Effects
Common Side Effects of Ketoconazole
Tell your doctor if any of the following side effects become severe or don't go away:
- Stomach pain, diarrhea, or constipation
- Heartburn or gas
- Change in the ability to taste
- Change in tongue color
- Dry mouth
- Difficulty sleeping
- Numbness, tingling, or burning of the hands or feet
- Hair loss
- Muscle pain
- Sensitivity to light
- Breast enlargement in men
- Decreased sexual ability
Serious Side Effects of Ketoconazole
Tell your doctor immediately if you experience any of the symptoms listed in the Warning section or any of the following serious side effects:
- Rash, hives, or itching
- Swelling of the eyes, face, lips, tongue, hands, feet, ankles, or lower legs
- Extreme tiredness
- Difficulty breathing or swallowing
Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking before taking ketoconazole, especially those listed in the Warning section or any of the following:
Ketoconazole comes as a tablet to take by mouth. It's typically taken once a day at around the same time.
The medicine also comes as a topical cream and shampoo.
The cream is usually applied once a day for two to six weeks.
The prescription shampoo is typically applied as a one-time treatment. The OTC shampoo is usually used every three to four days for up to eight weeks, and as needed after that.
Follow the directions on your prescription label carefully when taking this medicine. Don't take more or less of the drug than is prescribed.
Your doctor may increase your dose if your condition doesn't improve.
If you suspect an overdose, contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.
Missed Dose of Ketoconazole
If you miss a dose of ketoconazole, take it as soon as you remember.
However, if it's almost time for your next dose, skip the missed dose and continue on your regular dosing schedule.
Don't take extra medicine to make up for a missed dose.
By Lynn Marks | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2015-05-04
Copyright © 2014 Everyday Health Media, LLC
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Video: Ketoconazole tablet full Details
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